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Pulmonary surfactant, a lipid-protein complex that modulates surface tension at the respiratory air liquid interface to stabilise bronchoalveolar structure, plays a fundamental role in lung. Physiopathology of Respiratory Distress Syndrome. Risk factors of neonatal RDS. Several risk factors contribute to the development of RDS. Mechanical ventilators work by generating a pressure gradient within. Risk factors of neonatal RDS.